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GLP-1 Glossary

Key terms and definitions related to GLP-1 medications, weight loss research, and metabolic health.

GLP-1

Glucagon-like peptide-1: A hormone that regulates blood sugar and appetite. GLP-1 receptor agonists are medications that mimic this hormone.

Semaglutide

A GLP-1 receptor agonist used for weight loss and diabetes treatment. Brand names include Ozempic and Wegovy.

Tirzepatide

A dual GLP-1 and GIP receptor agonist. Marketed as Mounjaro for diabetes and Zepbound for weight loss.

GIP

Glucose-dependent insulinotropic polypeptide: Another incretin hormone that works alongside GLP-1 to regulate blood sugar.

Compounding

The process of creating customized medications tailored to individual patient needs, often done by licensed pharmacies.

503B Outsourcing Facility

A pharmacy facility registered with the FDA to compound medications in bulk, subject to higher quality standards.

PCAB

Pharmacy Compounding Accreditation Board: An organization that accredits compounding pharmacies to ensure quality and safety.

BMI

Body Mass Index: A measure of body fat based on height and weight. Used to determine eligibility for weight loss treatments.

SURMOUNT Trial

Clinical trials studying tirzepatide for obesity treatment. SURMOUNT-1 showed 22.5% average weight loss at 3 years.

STEP Trial

Semaglutide Treatment Effect in People with Obesity: Clinical trials demonstrating semaglutide's effectiveness for weight loss.

Cold Chain

A temperature-controlled supply chain required for peptide medications like GLP-1s to maintain potency and effectiveness.

Telehealth

The use of digital communication technologies to provide healthcare services remotely, including consultations and prescriptions.

Incretin

A group of hormones that stimulate insulin release after eating. GLP-1 is the most prominent incretin hormone.

Dual Agonist

A medication that activates multiple receptor types. Tirzepatide is a dual GLP-1 and GIP receptor agonist.

Medicare

Federal health insurance program for people 65 and older, and some younger individuals with disabilities.

Medicaid

Joint federal and state program that helps cover medical costs for people with limited income and resources.

cGMP

Current Good Manufacturing Practice: Quality assurance standards for pharmaceutical manufacturing required by the FDA.

Food Noise

A term used to describe constant thoughts about food and eating. GLP-1 medications are reported to reduce this.

A1C

A blood test measuring average blood sugar levels over 2-3 months. Used to diagnose and monitor diabetes.

Insulin Resistance

A condition where the body's cells don't respond well to insulin, leading to higher blood sugar levels.